Dating the endometrium

dating the endometrium

Does the endometrial response to hormone therapy vary by patient?

Although the endometrial response may vary from patient to patient, certain general histologic patterns for specific hormone therapies can be recognized. To comprehend the iatrogenic effect of exogenous hormone therapy, a review of the normal and abnormal endogenous hormone-related endometrial changes is appropriate.

What percentage of infertile women have an accelerated endometrium?

Result (s): At day LH+7, 42% infertile vs. 67% fertile women demonstrated endometria that were in phase (statistically nonsignificant difference). Nine percent had an accelerated endometrium, and 47% (infertile) vs. 24% (fertile) had a delayed endometrium (statistically nonsignificant difference).

What are the histopathologic changes of the uterus associated with endometriosis?

The histopathologic changes of the uterus, and particularly of the endometrium, associated with these therapies encompass a variety of morphologic features that are often difficult to interpret. The endometrium is a sensitive target tissue for steroid sex hormones and is able to modify its structural characteristics with promptness and versatility.

Where do secretory changes take place in the endometrium?

The secretory changes take place only in an estrogen-primed endometrium. The secretory activity in the second half of the menstrual cycle is characterized by a diversity of structural changes that are apparent on routine examination of endometrial biopsies, showing a different pattern on every day of the cycle.

What are the side effects of hormone replacement therapy for endometriosis?

Hormone replacement therapy with estrogen alone may result in continuous endometrial proliferation, hyperplasia, and neoplasia.

What are the histologic patterns of endometriosis associated with hormone therapy?

The histologic patterns of the endometrium associated with hormone therapy vary with the dosage, duration of therapy, and individual hormone receptor activity.

What is the effect of estrogen and progesterone on the endometrium?

The effect of OC on the endometrium is related to the dosage and potency of the hormones. The progesterone effect dominates over the estrogen effect. High-dose, high-potency OC produce endometrial stromal cell hyperplasia, decidual reaction, and glandular atrophy. The stromal hyperplasia may be atypical, suggestive of stromal neoplasms (8).

Can hormone therapy be used to treat endometrial cancer?

Hormone Therapy for Endometrial Cancer. This type of treatment uses hormones or hormone-blocking drugs to fight cancer. It’s not the same as the hormone therapy given to treat the symptoms of menopause (menopausal hormone therapy). Hormone treatment for endometrial cancer can include: Progestins (the main hormone treatment used)

What happens in the secretory phase of the endometrium?

In humans and other primates, coiled blood vessels called spiral arteries develop in the endometrium during this phase. Estradiol may also stimulate the production of receptor proteins for progesterone at this time, in preparation for the next phase of the cycle. The secretory phase of the endometrium occurs when the ovary is in its luteal phase.

What are the cyclic changes in the endometrium?

These changes occur because the development of the endometrium is timed by the cyclic changes in the secretion of estradiol and progesterone from the ovarian follicles. Three phases can be identified on the basis of changes in the endometrium: (1) the proliferative phase; (2) the secretory phase; and (3) the menstrual phase (fig. 20.35, bottom).

What are the three phases of the endometrium?

Three phases can be identified on the basis of changes in the endometrium: (1) the proliferative phase; (2) the secretory phase; and (3) the menstrual phase (fig. 20.35, bottom). The proliferative phase of the endometrium occurs while the ovary is in its follicular phase.

Where is glycogen produced and stored in the endometrium?

Production and storage of glycogen occurs at the basal pole of uterine glands. The endometrium differentiates itself beginning in the early secretory phase, beginning its development due to the hormone progesterone from the corpus luteum.

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